abstract：OBJECTIVE:To determine the risk of chronic kidney disease in patients with psoriasis. DESIGN:Population based cohort study and nested cross sectional study. SETTING:Electronic medical records database based in United Kingdom. PARTICIPANTS:Cohort study: patients with psoriasis aged 18-90 each matched to up to five pa...

journal_title：BMJ (Clinical research ed.)

authors： Wan J,Wang S,Haynes K,Denburg MR,Shin DB,Gelfand JM

更新日期：2013-10-15 00:00:00

abstract：OBJECTIVE:To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians. DESIGN:Pooled analyses of 20 prospective cohorts in Asia, including data from 835,082 east Asians and 289,815 south Asians. Cohorts w...

journal_title：BMJ (Clinical research ed.)

authors： Chen Y,Copeland WK,Vedanthan R,Grant E,Lee JE,Gu D,Gupta PC,Ramadas K,Inoue M,Tsugane S,Tamakoshi A,Gao YT,Yuan JM,Shu XO,Ozasa K,Tsuji I,Kakizaki M,Tanaka H,Nishino Y,Chen CJ,Wang R,Yoo KY,Ahn YO,Ahsan H,

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To investigate the effectiveness of supplementing information and advice on analgesia and exercise from a general practitioner with transcutaneous electrical nerve stimulation (TENS) as a non-drug form of analgesia to reduce pain intensity in patients with tennis elbow. DESIGN:Pragmatic randomised controlled...

journal_title：BMJ (Clinical research ed.)

authors： Chesterton LS,Lewis AM,Sim J,Mallen CD,Mason EE,Hay EM,van der Windt DA

更新日期：2013-09-02 00:00:00

abstract：OBJECTIVE:To identify historical and clinical findings at emergency department presentation associated with severe H1N1 outcome in children presenting with influenza-like illness. DESIGN:Multicentre retrospective case-control study. SETTING:79 emergency departments of hospitals associated with the Pediatric Emergency...

journal_title：BMJ (Clinical research ed.)

authors： Dalziel SR,Thompson JM,Macias CG,Fernandes RM,Johnson DW,Waisman Y,Cheng N,Acworth J,Chamberlain JM,Osmond MH,Plint A,Valerio P,Black KJ,Fitzpatrick E,Newton AS,Kuppermann N,Klassen TP,Pediatric Emergency Research Netwo

更新日期：2013-08-12 00:00:00

abstract：OBJECTIVE:To determine whether the novel avian influenza H7N9 virus can transmit from person to person and its efficiency. DESIGN:Epidemiological investigations conducted after a family cluster of two patients with avian H7N9 in March 2013. SETTING:Wuxi, Eastern China. PARTICIPANTS:Two patients, their close contacts...

journal_title：BMJ (Clinical research ed.)

authors： Qi X,Qian YH,Bao CJ,Guo XL,Cui LB,Tang FY,Ji H,Huang Y,Cai PQ,Lu B,Xu K,Shi C,Zhu FC,Zhou MH,Wang H

更新日期：2013-08-06 00:00:00

abstract：OBJECTIVES:To examine the individual and combined associations of unhealthy behaviours (low/intermediate physical activity, consuming fruit and vegetables less than once a day, current smoking/short term ex-smoking, never/former/heavy alcohol drinking), assessed at start of follow-up, with hazard of disability among ol...

journal_title：BMJ (Clinical research ed.)

authors： Artaud F,Dugravot A,Sabia S,Singh-Manoux A,Tzourio C,Elbaz A

更新日期：2013-07-23 00:00:00

abstract：OBJECTIVES:To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. DESIGN:Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument fo...

journal_title：BMJ (Clinical research ed.)

authors： Palmer TM,Nordestgaard BG,Benn M,Tybjærg-Hansen A,Davey Smith G,Lawlor DA,Timpson NJ

更新日期：2013-07-18 00:00:00

abstract：OBJECTIVE:To assess adjustment practices for primary outcomes of randomized controlled trials and their impact on the results. DESIGN:Meta-epidemiologic study. DATA SOURCES:25 biomedical journals with the highest impact factor according to Journal Citation Reports 2009. STUDY SELECTION:Randomized controlled trials p...

journal_title：BMJ (Clinical research ed.)

authors： Saquib N,Saquib J,Ioannidis JP

更新日期：2013-07-12 00:00:00

abstract：OBJECTIVES:To investigate the association between intake of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of breast cancer and to evaluate the potential dose-response relation. DESIGN:Meta-analysis and systematic review of prospective cohort studies. DATA SOURCES:PubMed and Embase up to December 20...

journal_title：BMJ (Clinical research ed.)

authors： Zheng JS,Hu XJ,Zhao YM,Yang J,Li D

更新日期：2013-06-27 00:00:00

abstract：OBJECTIVE:To characterise the complete case series of influenza A/H7N9 infections as of 27 May 2013, detected by China's national sentinel surveillance system for influenza-like illness. DESIGN:Case series. SETTING:Outpatient clinics and emergency departments of 554 sentinel hospitals across 31 provinces in mainland ...

journal_title：BMJ (Clinical research ed.)

authors： Ip DK,Liao Q,Wu P,Gao Z,Cao B,Feng L,Xu X,Jiang H,Li M,Bao J,Zheng J,Zhang Q,Chang Z,Li Y,Yu J,Liu F,Ni MY,Wu JT,Cowling BJ,Yang W,Leung GM,Yu H

更新日期：2013-06-24 00:00:00

abstract：OBJECTIVE:To investigate estimation of calorie (energy) content of meals from fast food restaurants in adults, adolescents, and school age children. DESIGN:Cross sectional study of repeated visits to fast food restaurant chains. SETTING:89 fast food restaurants in four cities in New England, United States: McDonald's...

journal_title：BMJ (Clinical research ed.)

authors： Block JP,Condon SK,Kleinman K,Mullen J,Linakis S,Rifas-Shiman S,Gillman MW

更新日期：2013-05-23 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of an intervention to enhance self management support for patients with chronic conditions in UK primary care. DESIGN:Pragmatic, two arm, cluster randomised controlled trial. SETTING:General practices, serving a population in northwest England with high levels of deprivation. ...

journal_title：BMJ (Clinical research ed.)

authors： Kennedy A,Bower P,Reeves D,Blakeman T,Bowen R,Chew-Graham C,Eden M,Fullwood C,Gaffney H,Gardner C,Lee V,Morris R,Protheroe J,Richardson G,Sanders C,Swallow A,Thompson D,Rogers A,Salford National Institute for Health R

更新日期：2013-05-13 00:00:00

abstract：OBJECTIVE:To describe the experiences of authors of Cochrane reviews in searching for, getting access to, and using unpublished data. DESIGN:Cross sectional study. SETTING:Cochrane reviews. PARTICIPANTS:2184 corresponding authors of Cochrane reviews as of May 2012. MAIN OUTCOME MEASURE:Frequencies of responses to o...

journal_title：BMJ (Clinical research ed.)

authors： Schroll JB,Bero L,Gøtzsche PC

更新日期：2013-04-23 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of two peritendinous autologous blood injections in addition to a standardised eccentric calf strengthening programme in improving pain and function in patients with mid-portion Achilles tendinopathy. DESIGN:Single centre, participant and single assessor blinded, parallel group, r...

journal_title：BMJ (Clinical research ed.)

authors： Bell KJ,Fulcher ML,Rowlands DS,Kerse N

更新日期：2013-04-18 00:00:00

abstract：OBJECTIVE:To quantify an association between acute kidney injury and use of high potency statins versus low potency statins. DESIGN:Retrospective observational analysis of administrative databases, using nine population based cohort studies and meta-analysis. We performed as treated analyses in each database with a ne...

journal_title：BMJ (Clinical research ed.)

authors： Dormuth CR,Hemmelgarn BR,Paterson JM,James MT,Teare GF,Raymond CB,Lafrance JP,Levy A,Garg AX,Ernst P,Canadian Network for Observational Drug Effect Studies.

更新日期：2013-03-18 00:00:00

abstract：OBJECTIVES:To identify factors that differentiate between effective and ineffective computerised clinical decision support systems in terms of improvements in the process of care or in patient outcomes. DESIGN:Meta-regression analysis of randomised controlled trials. DATA SOURCES:A database of features and effects of...

journal_title：BMJ (Clinical research ed.)

authors： Roshanov PS,Fernandes N,Wilczynski JM,Hemens BJ,You JJ,Handler SM,Nieuwlaat R,Souza NM,Beyene J,Van Spall HG,Garg AX,Haynes RB

更新日期：2013-02-14 00:00:00

abstract：OBJECTIVES:To examine the association between income inequality and the risk of mortality and readmission within 30 days of hospitalization. DESIGN:Retrospective cohort study of Medicare beneficiaries in the United States. Hierarchical, logistic regression models were developed to estimate the association between inco...

journal_title：BMJ (Clinical research ed.)

authors： Lindenauer PK,Lagu T,Rothberg MB,Avrunin J,Pekow PS,Wang Y,Krumholz HM

更新日期：2013-02-14 00:00:00

abstract：OBJECTIVES:To determine the accuracy of a clinical decision rule (the traffic light system developed by the National Institute for Health and Clinical Excellence (NICE)) for detecting three common serious bacterial infections (urinary tract infection, pneumonia, and bacteraemia) in young febrile children. DESIGN:Retro...

journal_title：BMJ (Clinical research ed.)

authors： De S,Williams GJ,Hayen A,Macaskill P,McCaskill M,Isaacs D,Craig JC

更新日期：2013-02-13 00:00:00

abstract：OBJECTIVE:To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease. DESIGN:Prospective longitudinal cohort study. SETTING:Swedish mammography cohort, a population based cohort established in 1987-90. PARTICIPANTS:61 433 women (bo...

journal_title：BMJ (Clinical research ed.)

authors： Michaëlsson K,Melhus H,Warensjö Lemming E,Wolk A,Byberg L

更新日期：2013-02-12 00:00:00

abstract：OBJECTIVE:To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. DESIGN:Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116,056...

journal_title：BMJ (Clinical research ed.)

authors： Heikkilä K,Nyberg ST,Theorell T,Fransson EI,Alfredsson L,Bjorner JB,Bonenfant S,Borritz M,Bouillon K,Burr H,Dragano N,Geuskens GA,Goldberg M,Hamer M,Hooftman WE,Houtman IL,Joensuu M,Knutsson A,Koskenvuo M,Koskinen A

更新日期：2013-02-07 00:00:00

abstract：OBJECTIVE:To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. DESIGN:Cross sectional multicentre study. SETTING:49 public hospitals in major cities in Argentina, from September 2010 to May 2011. PARTICIPANTS:30,448 mothers (7293 vaccinated) and their 30,76...

journal_title：BMJ (Clinical research ed.)

authors： Rubinstein F,Micone P,Bonotti A,Wainer V,Schwarcz A,Augustovski F,Pichon Riviere A,Karolinski A,EVA Study Research Group Estudio Embarazo y Vacuna Antigripal.

更新日期：2013-02-04 00:00:00

abstract：OBJECTIVE:To quantify the impact of citalopram and other selective serotonin reuptake inhibitors on corrected QT interval (QTc), a marker of risk for ventricular arrhythmia, in a large and diverse clinical population. DESIGN:A cross sectional study using electrocardiographic, prescribing, and clinical data from electr...

journal_title：BMJ (Clinical research ed.)

authors： Castro VM,Clements CC,Murphy SN,Gainer VS,Fava M,Weilburg JB,Erb JL,Churchill SE,Kohane IS,Iosifescu DV,Smoller JW,Perlis RH

更新日期：2013-01-29 00:00:00

abstract：OBJECTIVE:To assess the risk of epileptic seizures in people with and without epilepsy after vaccination with a monovalent AS03 adjuvanted pandemic A/H1N1 influenza vaccine (Pandemrix; Glaxo SmithKline, Sweden). DESIGN:Register based self controlled case series. SETTING:Three Swedish counties (source population 750,0...

journal_title：BMJ (Clinical research ed.)

authors： Arnheim-Dahlström L,Hällgren J,Weibull CE,Sparén P

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVE:To characterise the percentage of available outcome data being presented in reports of randomised clinical trials with continuous outcome measures, thereby determining the potential for incomplete reporting bias. DESIGN:Descriptive cross sectional study. DATA SOURCES:A random sample of 200 randomised trials...

journal_title：BMJ (Clinical research ed.)

authors： Schriger DL,Savage DF,Altman DG

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVES:To investigate the effectiveness of non-benzodiazepine hypnotics (Z drugs) and associated placebo responses in adults and to evaluate potential moderators of effectiveness in a dataset used to approve these drugs. DESIGN:Systematic review and meta-analysis. DATA SOURCE:US Food and Drug Administration (FDA)...

journal_title：BMJ (Clinical research ed.)

authors： Huedo-Medina TB,Kirsch I,Middlemass J,Klonizakis M,Siriwardena AN

更新日期：2012-12-17 00:00:00

abstract：OBJECTIVE:To characterise the functional morphology of the nasal microcirculation in humans in comparison with reindeer as a means of testing the hypothesis that the luminous red nose of Rudolph, one of the most well known reindeer pulling Santa Claus's sleigh, is due to the presence of a highly dense and rich nasal mi...

journal_title：BMJ (Clinical research ed.)

authors： Ince C,van Kuijen AM,Milstein DM,Yürük K,Folkow LP,Fokkens WJ,Blix AS

更新日期：2012-12-14 00:00:00

abstract：OBJECTIVE:To assess the association between mind wandering (thinking unrelated to the task at hand) and the risk of being responsible for a motor vehicle crash. DESIGN:Responsibility case-control study. SETTING:Adult emergency department of a university hospital in France, April 2010 to August 2011. PARTICIPANTS:955...

journal_title：BMJ (Clinical research ed.)

authors： Galéra C,Orriols L,M'Bailara K,Laborey M,Contrand B,Ribéreau-Gayon R,Masson F,Bakiri S,Gabaude C,Fort A,Maury B,Lemercier C,Cours M,Bouvard MP,Lagarde E

更新日期：2012-12-13 00:00:00

abstract：OBJECTIVE:To quantify the association between exposure to higher temperatures and the risk of myocardial infarction at an hourly temporal resolution. DESIGN:Case-crossover study. SETTING:England and Wales Myocardial Ischaemia National Audit Project (MINAP) database. PARTICIPANTS:24,861 hospital admissions for myocar...

journal_title：BMJ (Clinical research ed.)

authors： Bhaskaran K,Armstrong B,Hajat S,Haines A,Wilkinson P,Smeeth L

更新日期：2012-12-13 00:00:00

abstract：OBJECTIVE:To investigate the relation between total fat intake and body weight in adults and children. DESIGN:Systematic review and meta-analysis of randomised controlled trials and cohort studies. DATA SOURCES:Medline, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials to June 2010. INCLUSION CR...

journal_title：BMJ (Clinical research ed.)

authors： Hooper L,Abdelhamid A,Moore HJ,Douthwaite W,Skeaff CM,Summerbell CD

更新日期：2012-12-06 00:00:00

abstract：OBJECTIVE:To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN:Prospective national cohort studies, EPICure and EPICure 2. SETTING:Hospital and home based evaluations, ...

journal_title：BMJ (Clinical research ed.)

authors： Moore T,Hennessy EM,Myles J,Johnson SJ,Draper ES,Costeloe KL,Marlow N

更新日期：2012-12-04 00:00:00

abstract：OBJECTIVES:To examine the risk of atrial fibrillation in relation to the whole spectrum of thyroid function in a large cohort of patients. DESIGN:Population based cohort study of general practice patients identified by linkage of nationwide registries at the individual level. SETTING:Primary care patients in the city...

journal_title：BMJ (Clinical research ed.)

authors： Selmer C,Olesen JB,Hansen ML,Lindhardsen J,Olsen AM,Madsen JC,Faber J,Hansen PR,Pedersen OD,Torp-Pedersen C,Gislason GH

更新日期：2012-11-27 00:00:00

abstract：OBJECTIVE:To investigate clinical trialists' opinions and experiences of sharing of clinical trial data with investigators who are not directly collaborating with the research team. DESIGN AND SETTING:Cross sectional, web based survey. PARTICIPANTS:Clinical trialists who were corresponding authors of clinical trials ...

journal_title：BMJ (Clinical research ed.)

authors： Rathi V,Dzara K,Gross CP,Hrynaszkiewicz I,Joffe S,Krumholz HM,Strait KM,Ross JS

更新日期：2012-11-20 00:00:00

abstract：OBJECTIVE:To investigate the risks of adverse pregnancy and birth outcomes for treated and untreated bipolar disorder during pregnancy. DESIGN:Population based cohort study using data from national health registers. SETTING:Sweden. PARTICIPANTS:332,137 women with a last menstrual period anytime after 1 July 2005 and...

journal_title：BMJ (Clinical research ed.)

authors： Bodén R,Lundgren M,Brandt L,Reutfors J,Andersen M,Kieler H

更新日期：2012-11-08 00:00:00

abstract：OBJECTIVE:To do an indirect comparison analysis of apixaban against dabigatran etexilate (2 doses) and rivaroxaban (1 dose), as well as of rivaroxaban against dabigatranetexilate (2 doses), for their relative efficacy and safety against each other, with particular focus on the secondary prevention population for stroke...

journal_title：BMJ (Clinical research ed.)

authors： Rasmussen LH,Larsen TB,Graungaard T,Skjøth F,Lip GY

更新日期：2012-11-05 00:00:00

abstract：OBJECTIVES:To evaluate the cost effectiveness of human papillomavirus testing after treatment for cervical intraepithelial neoplasia (CIN). DESIGN:Economic analysis using a Markov modelling approach to combine cost and epidemiological data from the NHS Sentinel Sites Study with data from previous studies of post-treat...

journal_title：BMJ (Clinical research ed.)

authors： Legood R,Smith M,Lew JB,Walker R,Moss S,Kitchener H,Patnick J,Canfell K

更新日期：2012-10-31 00:00:00

abstract：OBJECTIVE:To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications. DESIGN:Prospective, propensity score matched cohort study. SETTING:General teaching hospital in Boston, Massachusetts, United States, 20...

journal_title：BMJ (Clinical research ed.)

authors： Grosse-Sundrup M,Henneman JP,Sandberg WS,Bateman BT,Uribe JV,Nguyen NT,Ehrenfeld JM,Martinez EA,Kurth T,Eikermann M

更新日期：2012-10-15 00:00:00

abstract：OBJECTIVE:To determine the most effective tocolytic agent at delaying delivery. DESIGN:Systematic review and network meta-analysis. DATA SOURCES:Cochrane Central Register of Controlled Trials, Medline, Medline In-Process, Embase, and CINAHL up to 17 February 2012. STUDY SELECTION:Randomised controlled trials of toco...

journal_title：BMJ (Clinical research ed.)

authors： Haas DM,Caldwell DM,Kirkpatrick P,McIntosh JJ,Welton NJ

更新日期：2012-10-09 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of classroom based cognitive behavioural therapy with attention control and usual school provision for adolescents at high risk of depression. DESIGN:Three arm parallel cluster randomised controlled trial. SETTING:Eight UK secondary schools. PARTICIPANTS:Adolescents (n=5030) ag...

journal_title：BMJ (Clinical research ed.)

authors： Stallard P,Sayal K,Phillips R,Taylor JA,Spears M,Anderson R,Araya R,Lewis G,Millings A,Montgomery AA

更新日期：2012-10-05 00:00:00

abstract：OBJECTIVE:To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. DESIGN:Retrospective cohort study (GENE-RAD-RISK). SETTING:Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, PARTICIPANTS:1993 female carriers of BRC...

journal_title：BMJ (Clinical research ed.)

authors： Pijpe A,Andrieu N,Easton DF,Kesminiene A,Cardis E,Noguès C,Gauthier-Villars M,Lasset C,Fricker JP,Peock S,Frost D,Evans DG,Eeles RA,Paterson J,Manders P,van Asperen CJ,Ausems MG,Meijers-Heijboer H,Thierry-Chef I,Hau

更新日期：2012-09-06 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of interventions designed to improve outcomes in patients with multimorbidity in primary care and community settings. DESIGN:Systematic review. DATA SOURCES:Medline, Embase, CINAHL, CAB Health, Cochrane central register of controlled trials, the database of abstracts of review...

journal_title：BMJ (Clinical research ed.)

authors： Smith SM,Soubhi H,Fortin M,Hudon C,O'Dowd T

更新日期：2012-09-03 00:00:00